As she squats by a roadside burning all of her documentation on the snake research, one of Murdoch's men named Peter Resyner drives by heading for the factory where he finds one baby snake still alive and delivers the snake to Murdoch.The villainous Imhotep plots to destroy all the world's snakes. Once she is at a safe distance, the explosives detonate, killing Hammett and the baby snakes. After wounding Hammett, Amanda sets the timer on the explosives and escapes from the building, leaving Hammett to be attacked by the baby snakes while he tries to reach the bomb. Inside the building, the queen gives birth. As the two of them meet Amanda inside the factory, Andrei moves to set the charges, but Hammett kills him, causing Amanda to realize that Hammett is working for Murdoch who wants a live baby anaconda.
Hammett and his last remaining hunter, Andrei, arrive after hearing the grenade go off. Nick helps Amanda escape, but is wounded by the snake as it impales him with its tail, but Nick is able to discharge a grenade, killing both him and the snake. Before they can finish, the snake attacks. While Hammett searches for the snake on foot, Amanda and one of the three remaining hunters, Nick, spot the snakes first going into an old factory and follow them in to plant explosives around the building. In the morning, the party begins searching for the snake, but Pinkus is stabbed in the chest by the anaconda and is killed. The teams want to call in the military, but Hammett forbids it and threatens Amanda with jail for her role in creating it. Amanda is rescued by Hammett and both of them escape.Īs they regroup, Amanda reluctantly reveals that the queen snake is pregnant and will give birth to more genetically "special" offspring in less than 24 hours. As Amanda tries to leave the car to help her, the snake reappears and devours Sofia. The car crashes and Sofia is thrown from the car, breaking her leg in the process. During the next confrontation with the snake, the anaconda spits acidic venom in Victor's face, burning it. As the group splits up, Amanda heads off in a car with two other team members, Victor and Sofia.
Hammett arrives and gives the team a lecture on how to kill the snake. During the first confrontation with the snake, two of the party are killed: Grozny is stabbed by the genetically altered anaconda's very sharp tail and Dragosh gets his head bitten off by the snake. The hunting party arrives later and begin formulating a plan of attack. At a small farm in the middle of the woods, the owner is eaten alive by one of the snakes. Murdoch calls in a team of animal hunters, led by Stephen Hammett to capture both snakes. The anaconda soon sneaks up behind them and crushes the professor to death in its coils and bites his head off. In looking through the facility, Amanda and the professor realize that the anaconda also freed the queen anaconda. As it escapes, it kills many of the people working in the laboratory. However, as Murdoch, his assistant Pinkus and Daryl are about to leave, the anaconda kills Daryl and breaks through the enclosure's wall. While visiting the facility, Murdoch provokes the anaconda with a large flashlight, and has it gassed to calm it down. Amanda Hayes and funded by Peter "J.D." Murdoch, a well-known industrialist.
In Romania, an anaconda that was captured from the Amazon River is being held at a genetic research facility owned by Wexel Hall for experimentation when Professor Eric Kane has developed a serum for the Blood Orchid (the one recovered from the fountain after the ruins of the Borneo jungle).